Which of the following describes a disadvantage of using a multi-leaf collimator (MLC)?

The option that highlights the disadvantage of using a multi-leaf collimator (MLC) is correct because MLCs necessitate intricate planning and calibration to effectively shape the radiation beam for each patient's treatment. The complexity arises from the need to carefully account for the precise positioning and movement of the collimator leaves to achieve the desired radiation distribution. This requires advanced treatment planning systems, sophisticated algorithms, and a thorough understanding of the treatment anatomy.

Additionally, the precision in using MLCs means that dosimetrists and radiation oncologists must collaborate closely to ensure that the treatment plan meets the patient's specific needs, which can be time-consuming and requires a higher level of technical expertise compared to simpler methods. As a result, the requirement for more intensive planning and calibration is a significant consideration when using MLCs in clinical practice.